Picornaviridae
Study Group
Pages		 Cardiovirus B
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Cardiovirus A
Cardiovirus B
Cardiovirus C
 

New and Re-classified Types

Genus Cardiovirus, species Cardiovirus B

Viruses: Theiler's murine encephalomyelitis virus,

Vilyuisk human encephalomyelitis virus,

Thera virus &

Saffold virus 

New type Strain ID Species Proposer Supporting data Reference(s)
Thera virus* NGS910 rat Nick Knowles

Nearly CG [AB090161]

 Ohsawa et al., 2003
Saffold virus 1 California/81 human Nick Knowles Nearly CG [EF165067] Jones et al., 2007
Saffold virus 2 Can112051-06 human Nick Knowles polyprotein-coding region
[AM922293]		 Abed and Boivin,
2008
Saffold virus 3 D/VI2273/2004 human Nick Knowles P1 [EU681178] Drexler et al., 2008
Saffold virus 4 Pak5842 human Eric Delwart VP1 [FJ463606] Blinkova et al., 2009
Saffold virus 5 Pak5003 human Eric Delwart Nearly CG [FJ463615] Blinkova et al., 2009
Saffold virus 6 Pak6572 human Eric Delwart Nearly CG [FJ463617] Blinkova et al., 2009
Saffold virus 7 Afg1449 human Eric Delwart VP1 [FJ463602] Blinkova et al., 2009
Saffold virus 8 Pak1141 human Eric Delwart VP1 [FJ463604] Blinkova et al., 2009
Saffold virus 9 Nig239 human Olga Blinkova VP1 [FJ997532] Blinkova, unpub.
Saffold virus 10 Pak-2325 human A. Naeem and H. Shimizu CG [AB747257] Naeem & Shimizu, unpub.
Saffold virus 11 Pak-2338 human A. Naeem and H. Shimizu CG [AB747258] Naeem & Shimizu, unpub.

CG, complete genome sequence
*, formerly "Theiler-like virus of rats"; for new name see Liang et al., 2008.
Complete genome sequences are now available for SAFV-1 to 11

References
Abed, Y. and Boivin, G. (2008). New Saffold cardioviruses in 3 children, Canada. Emerging Infectious Diseases 14: 000-000 (in press); 2008 May; [Epub ahead of print].

Blinkova, O., Kapoor, A., Victoria, J., Naeem, A., Shaukat, S., Sharif, S., Alam, M.M., Angez, M., Zaidi, S. and Delwart, E.L. (2009). Cardioviruses are genetically 1 diverse and common enteric infections in South Asian children. J. Virol. Ahead of print on 4 February 2009; doi:10.1128/JVI.02085-08.

Drexler, J.F., de Souza Luna, L.K., Stöcker, A., Silva Almeida, P., Medrado Ribeiro, T.C., Petersen, N., Herzog, P., Pedroso, C., Huppertz, H.I., da Costa Ribeiro, H. Jr., Baumgarte, S. and Drosten, C. (2008). Circulation of 3 lineages of a novel saffold cardiovirus in humans. Emerg. Infect. Dis. 14: 1398-1405.
 
Jones, M.S., Lukashov, V.V., Ganac, R.D., Schnurr, D.P. (2007). Discovery of a novel human picornavirus from a pediatric patient presenting with fever of unknown origin. J. Clin. Microbiol. 45: 2144-2150.

Liang, Z., Manoj Kumar, A.S., Jones, M.S., Knowles, N.J. and Lipton, H.L. (2008). Phylogenetic analysis of the species Theilovirus: emerging murine and human pathogens. Journal of Virology 82: 11545–11554.
 
Ohsawa, K., Watanabe, Y., Miyata, H. and Sato, H. (2003). Genetic analysis of a Theiler's-like virus isolated from rats. Comparative Medicine 53: 44-49. [Kazutaka Ohsawa, Nagasaki University School of Medicine, Laboratory Animal Center for Biomedical Research; 1-12-4 Sakamoto, Nagasaki, Nagasaki 852-8523, Japan. E-mail: kohsawa@net.nagasaki-u.ac.jp; Tel: 81-95-849-7134; Fax: 81-95-849-7148]